Association between macrocalcification and papillary thyroid carcinoma and corresponding valuable diagnostic tool: retrospective study

World Journal of Surgical Oncology

Research

Wenjun Wu¹  Xiaojun Chen¹  Xiaohua Gong¹  Qi Zhou¹  Shan Wu²  Mengyao Ye³  Fang Wang⁴ 

[1] Department of Endocrinology, First Affiliated Hospital of Wenzhou Medical University, 325015, Wenzhou, Zhejiang, China;Department of Endocrinology, People’s Hospital of Yuhuan, 318000, Taizhou, Zhejiang, China;Department of Endocrinology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, 325015, Wenzhou, Zhejiang, China;Department of Endocrinology, First Affiliated Hospital of Wenzhou Medical University, 325015, Wenzhou, Zhejiang, China;Departments of Pathology, First Affiliated Hospital of Wenzhou Medical University, 325015, Wenzhou, Zhejiang, China;

关键词: Thyroid nodule;    Papillary thyroid carcinoma;    Macrocalcification;    Fine needle aspiration biopsy;    Proto-Oncogene Proteins B-raf V600E;   

DOI  :  10.1186/s12957-023-03016-7

 received in 2023-02-16, accepted in 2023-04-08,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundMicrocalcifications are suggested to be an indicator of thyroid malignancy, especially for papillary thyroid carcinoma (PTC), nonetheless, the association between macrocalcification and PTC is underexplored. Furthermore, screening methods like ultrasonography and ultrasound-guided fine needle aspiration biopsy (US-FNAB) are limited in evaluating macro-calcified thyroid nodules. Thus, we aimed to investigate the relationship between macrocalcification and PTC. We also explored the diagnostic efficiency of US-FNAB and proto-Oncogene Proteins B-raf V600E (BRAF V600E) mutation in macro-calcified thyroid nodules evaluation.MethodsA retrospective research of 2645 thyroid nodules from 2078 participants was performed and divided into three groups as non-, micro-, and macro-calcified for further PTC incidence comparison. Besides, a total of 100 macro-calcified thyroid nodules with both results of US-FNAB and BRAF V600E mutation were screened out for subsequent evaluation of diagnostic efficiency.ResultsCompared to non-calcification, macrocalcification showed a significantly higher incidence of PTC (31.5% vs. 23.2%, P<0.05). Additionally, when compared with a single US-FNAB, the combination of US-FNAB and BRAF V600E mutation showed better diagnostic efficiency in diagnosing macro-calcified thyroid nodule (area under the curve (AUC) 0.94 vs. 0.84, P=0.03), with a significantly higher sensitivity (100.0% vs. 67.2%, P<0.01) and a comparable standard of specificity (88.9% vs. 100.0%, P=0.13).ConclusionsOccurrence of macrocalcification in thyroid nodules may suggest a high risk of PTC, and the combination of US-FNAB and BRAF V600E showed a greater value in identifying macro-calcified thyroid nodules, especially with significantly higher sensitivity.Trial registrationThe Ethics Committee of The First Affiliated Hospital of Wenzhou Medical University (2018-026).

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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Fig. 1

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