What data collection methods work best for COVID19 outbreak surveillance for people with end stage kidney disease? An observational cohort study using the UK Renal Registry

BMC Nephrology

Research

Fran Benoy-Deeney¹  Retha Steenkamp¹  Shalini Santhakumaran¹  Manuela Savino²  Dorothea Nitsch³  James Medcalf⁴ 

[1] UK Renal Registry, Brandon House Building 20A1 Southmead Road Filton, BS34 7RR, Bristol, UK;UK Renal Registry, Brandon House Building 20A1 Southmead Road Filton, BS34 7RR, Bristol, UK;Great Western Hospital NHS Foundation Trust, Swindon, UK;UK Renal Registry, Brandon House Building 20A1 Southmead Road Filton, BS34 7RR, Bristol, UK;London School of Hygiene and Tropical Medicine, London, UK;Royal Free London NHS Foundation Trust, London, UK;UK Renal Registry, Brandon House Building 20A1 Southmead Road Filton, BS34 7RR, Bristol, UK;University of Leicester, Leicester, UK;Leicester General Hospital, Leicester, UK;

关键词: COVID-19;    ESKD;    Surveillance;    Infection;    Dialysis;    KRT;   

DOI  :  10.1186/s12882-023-03148-8

 received in 2022-07-06, accepted in 2023-03-31,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPatients on kidney replacement therapy (KRT) are vulnerable to severe illness from COVID-19. Timely, accurate surveillance is essential for planning and implementing infection control at local, regional and national levels. Our aim was to compare two methods of data collection for COVID-19 infections amongst KRT patients in England.MethodsAdults receiving KRT in England were linked to two sources of data on positive COVID-19 tests recorded March-August 2020: (1) submissions from renal centres to the UK Renal Registry (UKRR) and (2) Public Health England (PHE) laboratory data. Patient characteristics, cumulative incidence by modality (in-centre haemodialysis (ICHD), home HD, peritoneal dialysis (PD) and transplant), and 28-day survival were compared between the two sources.Results2,783/54,795 patients (5.1%) had a positive test in the combined UKRR-PHE dataset. Of these 2,783, 87% had positive tests in both datasets. Capture was consistently high for PHE (> 95% across modalities) but varied for UKRR (ranging from ICHD 95% to transplant 78%, p < 0.0001). Patients captured only by PHE were more likely to be on transplant or home therapies (OR 3.5 95% CI [2.3–5.2] vs. ICHD) and to be infected in later months (OR 3.3 95%CI [2.4–4.6] for May-June, OR 6.5 95%CI [3.8–11.3] for July-August, vs. March-April), compared to patients in both datasets. Stratified by modality, patient characteristics and 28-day survival were similar between datasets.ConclusionsFor patients undergoing ICHD treatment the collection of data submitted directly by renal centres allows constant monitoring in real time. For other KRT modalities, using a national swab test dataset through frequent linkage may be the most effective method. Optimising central surveillance can improve patient care by informing interventions and assisting planning at local, regional and national levels.

【 授权许可】

CC BY   
© The Author(s) 2023

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