Abnormal glycosylation in glioma: related changes in biology, biomarkers and targeted therapy

Biomarker Research

Review

Zhaohui Luo¹  Bo Xiao¹  Juan Yue²  Roujie Huang³  Zehao Lan⁴ 

[1] Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya road of Kaifu district, 410008, Changsha, Hunan, China;Clinical Research Center for Epileptic disease of Hunan Province, Central South University, 410008, Changsha, Hunan, P.R. China;Department of Neurology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Xiangya School of Medicine, Central South University, 410013, Changsha, Hunan, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, 87 Xiangya road of Kaifu district, 410008, Changsha, Hunan, China;Department of Obstetrics and Gynecology, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Shuaifuyuan No. 1, Dongcheng District, 100730, Beijing, China;Xiangya School of Medicine, Central South University, 410013, Changsha, Hunan, China;

关键词: Glycosylation;    Glioma;    Cancer progression;    Biomarkers;    Targeted therapy;   

DOI  :  10.1186/s40364-023-00491-8

 received in 2022-11-27, accepted in 2023-04-26,  发布年份 2023

来源: Springer

【 摘 要 】

Glioma is a rapidly growing and aggressive primary malignant tumor of the central nervous system that can diffusely invade the brain tissue around, and the prognosis of patients is not significantly improved by traditional treatments. One of the most general posttranslational modifications of proteins is glycosylation, and the abnormal distribution of this modification in gliomas may shed light on how it affects biological behaviors of glioma cells, including proliferation, migration, and invasion, which may be produced by regulating protein function, cell—matrix and cell‒cell interactions, and affecting receptor downstream pathways. In this paper, from the perspective of regulating protein glycosylation changes and abnormal expression of glycosylation-related proteins (such as glycosyltransferases in gliomas), we summarize how glycosylation may play a crucial role in the discovery of novel biomarkers and new targeted treatment options for gliomas. Overall, the mechanistic basis of abnormal glycosylation affecting glioma progression remains to be more widely and deeply explored, which not only helps to inspire researchers to further explore related diagnostic and prognostic markers but also provides ideas for discovering effective treatment strategies and improving glioma patient survival and prognosis.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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