Gastric cancer treatment: recent progress and future perspectives

Journal of Hematology & Oncology

Review

Rui-Hua Xu¹  Wen-Long Guan¹  Ye He¹ 

[1] Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, 651 Dongfeng Road East, 510060, Guangzhou, People’s Republic of China;Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, 510060, Guangzhou, People’s Republic of China;

关键词: Gastric cancer;    Perioperative chemotherapy;    Immunotherapy;    Targeted therapy;   

DOI  :  10.1186/s13045-023-01451-3

 received in 2023-03-13, accepted in 2023-05-10,  发布年份 2023

来源: Springer

【 摘 要 】

Gastric cancer (GC) is one of the most common malignancies worldwide. Most patients are diagnosed at advanced stages due to the subtle symptoms of earlier disease and the low rate of regular screening. Systemic therapies for GC, including chemotherapy, targeted therapy and immunotherapy, have evolved significantly in the past few years. For resectable GC, perioperative chemotherapy has become the standard treatment. Ongoing investigations are exploring the potential benefits of targeted therapy or immunotherapy in the perioperative or adjuvant setting. For metastatic disease, there have been notable advancements in immunotherapy and biomarker-directed therapies recently. Classification based on molecular biomarkers, such as programmed cell death ligand 1 (PD-L1), microsatellite instability (MSI), and human epidermal growth factor receptor 2 (HER2), provides an opportunity to differentiate patients who may benefit from immunotherapy or targeted therapy. Molecular diagnostic techniques have facilitated the characterization of GC genetic profiles and the identification of new potential molecular targets. This review systematically summarizes the main research progress in systemic treatment for GC, discusses current individualized strategies and presents future perspectives.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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