Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model

Basic and Clinical Andrology

Research Article

Wende Yang¹  Hongbo Wei¹  Xiaolei Ma¹  Zhenbin Zhang¹  Pan Nie¹  Zehong Chen¹ 

[1] Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, 510630, Guangzhou, China;

关键词: Skin-derived precursor;    Schwann cell;    Erectile dysfunction;    Bilateral cavernous nerve injury;    Cell therapy;    Nerve regeneration;    Précurseur dérivé de la Peau;    Cellule de Schwann;    Dysfonction érectile;    Lésion bilatérale du Nerf caverneux;    Thérapie cellulaire;    Régénération nerveuse;   

DOI  :  10.1186/s12610-023-00187-x

 received in 2022-11-13, accepted in 2023-01-12,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundThis study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury.ResultsThe skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum.ConclusionsImplantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.

【 授权许可】

CC BY   
© The Author(s) 2023

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