Basic and Clinical Andrology | |
Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model | |
Research Article | |
Wende Yang1  Hongbo Wei1  Xiaolei Ma1  Zhenbin Zhang1  Pan Nie1  Zehong Chen1  | |
[1] Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, 510630, Guangzhou, China; | |
关键词: Skin-derived precursor; Schwann cell; Erectile dysfunction; Bilateral cavernous nerve injury; Cell therapy; Nerve regeneration; Précurseur dérivé de la Peau; Cellule de Schwann; Dysfonction érectile; Lésion bilatérale du Nerf caverneux; Thérapie cellulaire; Régénération nerveuse; | |
DOI : 10.1186/s12610-023-00187-x | |
received in 2022-11-13, accepted in 2023-01-12, 发布年份 2023 | |
来源: Springer | |
【 摘 要 】
BackgroundThis study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury.ResultsThe skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum.ConclusionsImplantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.
【 授权许可】
CC BY
© The Author(s) 2023
【 预 览 】
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【 参考文献 】
- [1]
- [2]
- [3]
- [4]
- [5]
- [6]
- [7]
- [8]
- [9]
- [10]
- [11]
- [12]
- [13]
- [14]
- [15]
- [16]
- [17]
- [18]
- [19]
- [20]
- [21]
- [22]
- [23]
- [24]
- [25]
- [26]
- [27]
- [28]
- [29]
- [30]
- [31]
- [32]
- [33]
- [34]
- [35]
- [36]
- [37]
- [38]
- [39]
- [40]
- [41]
- [42]
- [43]
- [44]
- [45]
- [46]
- [47]
- [48]
- [49]
- [50]