An integrative review of nonobvious puzzles of cellular and molecular cardiooncology

Cellular & Molecular Biology Letters

Review

Andrzej Tykarski¹  Arkadiusz Niklas¹  Paweł Uruski¹  Justyna Mikuła-Pietrasik²  Daniel Rychlewski²  Aleksandra Leśniewska²  Krzysztof Książek²  Julia Matuszewska² 

[1] Department of Hypertensiology, Poznań University of Medical Sciences, Długa ½ Str., 61-848, Poznan, Poland;Department of Pathophysiology of Ageing and Civilization Diseases, Poznań University of Medical Sciences, Długa ½ Str., 61-848, Poznan, Poland;

关键词: Cardiooncology;    Cardiac cells;    Cardiotoxicity;    Vascular cells;   

DOI  :  10.1186/s11658-023-00451-y

 received in 2023-02-22, accepted in 2023-04-17,  发布年份 2023

来源: Springer

【 摘 要 】

Oncologic patients are subjected to four major treatment types: surgery, radiotherapy, chemotherapy, and immunotherapy. All nonsurgical forms of cancer management are known to potentially violate the structural and functional integrity of the cardiovascular system. The prevalence and severity of cardiotoxicity and vascular abnormalities led to the emergence of a clinical subdiscipline, called cardiooncology. This relatively new, but rapidly expanding area of knowledge, primarily focuses on clinical observations linking the adverse effects of cancer therapy with deteriorated quality of life of cancer survivors and their increased morbidity and mortality. Cellular and molecular determinants of these relations are far less understood, mainly because of several unsolved paths and contradicting findings in the literature. In this article, we provide a comprehensive view of the cellular and molecular etiology of cardiooncology. We pay particular attention to various intracellular processes that arise in cardiomyocytes, vascular endothelial cells, and smooth muscle cells treated in experimentally-controlled conditions in vitro and in vivo with ionizing radiation and drugs representing diverse modes of anti-cancer activity.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 1

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