Cell therapy in end-stage liver disease: replace and remodel

Stem Cell Research & Therapy

Review

Xu-Yong Wei¹  Jian Chen¹  Qiang Wei¹  Qiu-Min Zheng²  Hao Wu³  Yang-Bo Tang³  Xin-Hao Hu⁴  Xiao Xu⁴  Lan Chen⁵  Qi Huang⁵ 

[1] Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, China;Life Sciences Institute, Zhejiang University, 310058, Hangzhou, China;NHC Key Laboratory of Combined Multi-Organ Transplantation, 310003, Hangzhou, China;The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, 310053, Hangzhou, China;Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, 310006, Hangzhou, China;Zhejiang Chinese Medical University, 310053, Hangzhou, China;

关键词: Cell therapy;    Stem cell;    End-stage liver disease;    Cell transplantation;    Liver regeneration;   

DOI  :  10.1186/s13287-023-03370-z

 received in 2022-09-30, accepted in 2023-04-26,  发布年份 2023

来源: Springer

【 摘 要 】

Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50% or more. Although liver transplantation has emerged as the most efficient treatment for end-stage liver disease, its application has been limited by the scarcity of donor livers. The lack of acceptable donor organs implies that patients are at high risk while waiting for suitable livers. In this scenario, cell therapy has emerged as a promising treatment approach. Most of the time, transplanted cells can replace host hepatocytes and remodel the hepatic microenvironment. For instance, hepatocytes derived from donor livers or stem cells colonize and proliferate in the liver, can replace host hepatocytes, and restore liver function. Other cellular therapy candidates, such as macrophages and mesenchymal stem cells, can remodel the hepatic microenvironment, thereby repairing the damaged liver. In recent years, cell therapy has transitioned from animal research to early human studies. In this review, we will discuss cell therapy in end-stage liver disease treatment, especially focusing on various cell types utilized for cell transplantation, and elucidate the processes involved. Furthermore, we will also summarize the practical obstacles of cell therapy and offer potential solutions.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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