The effect of environmental factors on precocious puberty in children: a case–control study

BMC Pediatrics

Research

Qing Niu¹  Dandan Wang¹  Xu Wang¹  Yubing Wang¹  Sabitina Mrisho Mzava²  Mingzhi Zhang³  Francis Manyori Bigambo³ 

[1] Department of Endocrinology, Children’s Hospital of Nanjing Medical University, 72 Guangzhou Rd, 210008, Nanjing, China;Muhimbili National Hospital, P. O. Box 65000, Dar Es Salaam, Tanzania;School of Public Health, Nanjing Medical University, 211166, Nanjing, China;

关键词: Precocious puberty;    Cesarean section;    Secondhand smoke;    Child BMI;    Adequate sleep;    Children;   

DOI  :  10.1186/s12887-023-04013-1

 received in 2022-12-14, accepted in 2023-04-15,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundRecently the prevalence of precocious puberty development is increasing among Chinese children. Proper understanding of the risk factors for precocious puberty in children is pivotal as could help to improve children's health. This study aims to evaluate the effect of environmental factors on precocious puberty in children.MethodsWe matched the cases and controls by age at the ratio of 1:1 (201 cases and 201 controls) for girls and 1:4 (24 cases and 96 controls) for boys. We used conditional logistic regression to explore the effect of environmental factors on precocious puberty, and a random forest model to identify the most important risk factor.ResultsIn the multivariate regression, cesarean section (OR = 1.99, 95% CI: 1.05, 3.76), child body mass index [BMI] (OR = 1.25, 95% CI: 1.10, 1.43), maternal BMI (OR = 1.13, 95%CI: 1.01, 1.26), and exposure to secondhand smoke several times a month but less than once a week (OR = 4.09, 95%CI: 1.79,9.35), and almost every day (OR = 6.48, 95% CI: 2.14, 19.56) were risk factors for precocious puberty in girls. While maternal height (OR = 0.82, 95% CI: 0.75, 0.88), paternal height (OR = 0.91, 95% CI: 0.85, 0.98), bedtime at night (OR = 0.30, 95% CI: 0.17, 0.51), and night sleep (OR = 0.43, 95% CI: 0.21, 0.86) were protective factors. In boys, only exposure to secondhand smoke several times a month but less than once a week (OR = 7.94, 95% CI: 1.25, 50.33) was a risk factor for precocious puberty. In the random forest model, Child BMI was the most important risk factor for precocious puberty in girls.ConclusionsOur findings suggest that environmental factors were associated with precocious puberty in children, particularly in girls.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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