Live birth rates following individualized dosing algorithm of follitropin delta in a long GnRH agonist protocol

Reproductive Biology and Endocrinology

Research

Marcos Ferrando Serrano¹  Ernesto Bosch²  Juan Antonio García Velasco³  Per Larsson⁴  Manuel Fernández Sánchez⁵  Esther Santamaría López⁶  Bernadette Mannaerts⁷ 

[1] Fundacion IVI, Instituto Investigación Sanitaria La Fe, ES-46026, Valencia, Spain;IVI Bilbao, Bilbao, Valencia, Spain;Fundacion IVI, Instituto Investigación Sanitaria La Fe, ES-46026, Valencia, Spain;IVI Valencia, Valencia, Spain;Fundacion IVI, Instituto Investigación Sanitaria La Fe, ES-46026, Valencia, Spain;IVI-RMA Madrid, Madrid, Spain;Global Biometrics, Ferring Pharmaceuticals A/S, Amager Strandvej 405, 2770, Kastrup, Denmark;IVI-RMA Seville, Avenida Americo Vespucio 19, ES-41092, Seville, Spain;Department of Surgery, Universidad de Sevilla, ES-41004, Seville, Spain;Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, 41013, Seville, ES, Spain;Fundacion IVI, Instituto Investigación Sanitaria La Fe, ES-46026, Valencia, Spain;IVI-RMA Seville, Avenida Americo Vespucio 19, ES-41092, Seville, Spain;Fundacion IVI, Instituto Investigación Sanitaria La Fe, ES-46026, Valencia, Spain;Reproductive Medicine & Maternal Health, Ferring Pharmaceuticals A/S, Amager Strandvej 405, 2770, Kastrup, Denmark;

关键词: Long GnRH agonist;    Individualized dosing;    Follitropin delta;    Cumulative live birth rates;   

DOI  :  10.1186/s12958-023-01090-w

 received in 2022-10-14, accepted in 2023-04-06,  发布年份 2023

来源: Springer

【 摘 要 】

PurposeTo explore the efficacy and safety of individualized follitropin delta dosing, based on serum anti-Müllerian hormone (AMH) concentration and bodyweight, in a long gonadotropin-releasing hormone (GnRH) agonist protocol.MethodsClinical outcomes after one treatment cycle are reported in women with AMH: 5–35 pmol/L. Oocytes were inseminated by intracytoplasmic sperm injection, blastocyst transfer was on Day 5 and remaining blastocysts were cryopreserved. Data collection included live births and neonatal health follow-up for all fresh/frozen transfers performed within one year after treatment allocation.ResultsIn total, 104 women started stimulation, of whom 101 had oocyte recovery and 92 had blastocyst transfer. The average daily dose of follitropin delta was 11.0 ± 1.6 µg and the duration of stimulation was 10.3 ± 1.6 days. The mean number of oocytes was 12.5 ± 6.4, the mean number of blastocysts was 5.1 ± 3.4, and 85% had at least one good-quality blastocyst. Following mostly single blastocyst transfer (95%), the ongoing pregnancy rate was 43%, the live-birth rate was 43%, and the cumulative live-birth rate was 58% per started stimulation. There were 6 cases of early OHSS (5.8%) graded as mild (n = 3) and moderate (n = 3) and 6 cases of late OHSS (5.8%) graded as moderate (n = 3) and severe (n = 3).ConclusionIn this first evaluation of the individualized follitropin delta dosing in a long GnRH agonist protocol, the cumulative live-birth rate was high. A randomized trial comparing follitropin delta in a long GnRH agonist protocol versus in a GnRH antagonist protocol should provide further insight into the efficacy and safety of this treatment option.Trial registration numberNCT03564509; June 21, 2018.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

Fig. 35

40517_2023_256_Article_IEq163.gif