Molecularly imprinted polymers (MIPs): emerging biomaterials for cancer theragnostic applications

Biomaterials Research

Review

Chaima Amri¹  Euni Cho²  Jin-Ho Lee³  Min Seok Kang⁴  Hye Eun Choi⁴  Ki Su Kim⁵ 

[1] Department of Convergence Medical Sciences, School of Medicine, Pusan National University, 49 Busandaehak-Ro, 50612, Yangsan, Republic of Korea;School of Biomedical Convergence Engineering, Pusan National University, 49 Busandaehak-Ro, 50612, Yangsan, Republic of Korea;Department of Information Convergence Engineering, Pusan National University, 49 Busandaehak-Ro, 50612, Yangsan, Republic of Korea;School of Biomedical Convergence Engineering, Pusan National University, 49 Busandaehak-Ro, 50612, Yangsan, Republic of Korea;Department of Information Convergence Engineering, Pusan National University, 49 Busandaehak-Ro, 50612, Yangsan, Republic of Korea;Department of Convergence Medical Sciences, School of Medicine, Pusan National University, 49 Busandaehak-Ro, 50612, Yangsan, Republic of Korea;School of Chemical Engineering, Pusan National University, 2 Busandaehak-Ro 63 Beon-Gil, Geumjeong-Gu, 46241, Busan, Republic of Korea;School of Chemical Engineering, Pusan National University, 2 Busandaehak-Ro 63 Beon-Gil, Geumjeong-Gu, 46241, Busan, Republic of Korea;Department of Organic Material Science & Engineering, Pusan National University, 2 Busandaehak-Ro 63 Beon-Gil, Geumjeong-Gu, 46241, Busan, Republic of Korea;Institute of Advanced Organic Materials, Pusan National University, 2 Busandaehak-Ro 63 Beon-Gil, Geumjeong-Gu, 46241, Busan, Republic of Korea;

关键词: Molecular imprinted polymer;    Cancer;    Theragnostic;    Diagnostic;    Drug delivery;   

DOI  :  10.1186/s40824-023-00388-5

 received in 2023-02-03, accepted in 2023-04-30,  发布年份 2023

来源: Springer

【 摘 要 】

Cancer is a disease caused by abnormal cell growth that spreads through other parts of the body and threatens life by destroying healthy tissues. Therefore, numerous techniques have been employed not only to diagnose and monitor the progress of cancer in a precise manner but also to develop appropriate therapeutic agents with enhanced efficacy and safety profiles. In this regard, molecularly imprinted polymers (MIPs), synthetic receptors that recognize targeted molecules with high affinity and selectivity, have been intensively investigated as one of the most attractive biomaterials for theragnostic approaches. This review describes diverse synthesis strategies to provide the rationale behind these synthetic antibodies and provides a selective overview of the recent progress in the in vitro and in vivo targeting of cancer biomarkers for diagnosis and therapeutic applications. Taken together, the topics discussed in this review provide concise guidelines for the development of novel MIP-based systems to diagnose cancer more precisely and promote successful treatment.Graphical AbstractMolecularlyimprinted polymers (MIPs), synthetic receptors that recognize targetedmolecules with high affinity and selectivity, have beenintensively investigated as one of the most attractive biomaterials for cancertheragnostic approaches. This review describes diverse synthesis strategies toprovide the rationale behind these synthetic antibodies and provides a selective overview of the recent progress inthe in vitro and in vivo targeting of cancer biomarkersfor diagnosis and therapeutic applications. The topics discussed in this reviewaim to provide concise guidelines for the development of novel MIP-basedsystems to diagnose cancer more precisely and promote successful treatment.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2023_36_Article_IEq118.gif

41116_2023_36_Article_IEq91.gif

12888_2023_4816_Article_IEq3.gif

40517_2023_256_Article_IEq1.gif

41116_2023_36_Article_IEq56.gif

41116_2023_36_Article_IEq42.gif

41116_2023_36_Article_IEq20.gif

41116_2023_36_Article_IEq6.gif

Fig. 1

Fig. 24

40517_2023_256_Article_IEq133.gif

Fig. 1