Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation

Cell & Bioscience

Review

Yadong Wang¹  Kang Xu¹  Yawei Fu²  Yulong Yin²  Yue Chen² 

[1] Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, 410125, Changsha, China;Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, 410125, Changsha, China;College of Animal Science and Technology, Henan Agricultural University, 450000, Zhengzhou, China;

关键词: AHR;    AHR ligands;    Tryptophan;    Gut immunity;    Gut inflammation;   

DOI  :  10.1186/s13578-023-01046-y

 received in 2023-01-13, accepted in 2023-05-04,  发布年份 2023

来源: Springer

【 摘 要 】

Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that has significant immunotoxic effects. Activation of AHR has beneficial effects on intestinal immune responses, but inactivation or overactivation of AHR can lead to intestinal immune dysregulation and even intestinal diseases. Sustained potent activation of AHR by TCDD results in impairment of the intestinal epithelial barrier. However, currently, AHR research has been more focused on elucidating physiologic AHR function than on dioxin toxicity. The appropriate level of AHR activation plays a role in maintaining gut health and protecting against intestinal inflammation. Therefore, AHR offers a crucial target to modulate intestinal immunity and inflammation. Herein, we summarize our current understanding of the relationship between AHR and intestinal immunity, the ways in which AHR affects intestinal immunity and inflammation, the effects of AHR activity on intestinal immunity and inflammation, and the effect of dietary habits on intestinal health through AHR. Finally, we discuss the therapeutic role of AHR in maintaining gut homeostasis and relieving inflammation.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

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