Cancer cachexia: molecular mechanisms and treatment strategies

Journal of Hematology & Oncology

Review

Jabir Aliyu Muhammad¹  Yoseph Toni Wijaya¹  Ji Heon Chae¹  Tania Setiawan¹  Nadya Marcelina Julianto¹  Hyeok Lee¹  Hyog Young Kwon²  Ita Novita Sari³ 

[1] Department of Integrated Biomedical Science, Soonchunhyang University, 31151, Cheonan-Si, Republic of Korea;Department of Integrated Biomedical Science, Soonchunhyang University, 31151, Cheonan-Si, Republic of Korea;Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, 31151, Cheonan-Si, Republic of Korea;Soonchunhyang Institute of Medi-Bio Science (SIMS), Soonchunhyang University, 31151, Cheonan-Si, Republic of Korea;Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, 138673, Proteos, Singapore, Republic of Singapore;

关键词: Cancer;    Cachexia;    Sarcopenia;    Treatment;    Multi-organ;    Muscle wasting;   

DOI  :  10.1186/s13045-023-01454-0

 received in 2023-03-03, accepted in 2023-05-13,  发布年份 2023

来源: Springer

【 摘 要 】

Muscle wasting is a consequence of physiological changes or a pathology characterized by increased catabolic activity that leads to progressive loss of skeletal muscle mass and strength. Numerous diseases, including cancer, organ failure, infection, and aging-associated diseases, are associated with muscle wasting. Cancer cachexia is a multifactorial syndrome characterized by loss of skeletal muscle mass, with or without the loss of fat mass, resulting in functional impairment and reduced quality of life. It is caused by the upregulation of systemic inflammation and catabolic stimuli, leading to inhibition of protein synthesis and enhancement of muscle catabolism. Here, we summarize the complex molecular networks that regulate muscle mass and function. Moreover, we describe complex multi-organ roles in cancer cachexia. Although cachexia is one of the main causes of cancer-related deaths, there are still no approved drugs for cancer cachexia. Thus, we compiled recent ongoing pre-clinical and clinical trials and further discussed potential therapeutic approaches for cancer cachexia.

【 授权许可】

CC BY   
© The Author(s) 2023

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