Migraine with aura: less control over pain and fragrances?

The Journal of Headache and Pain

Research

Gudrun Gossrau¹  Marie Frost¹  Christoph M. Michel²  Thomas Hummel³  Antje Haehner³  Coralie Mignot³  Vanda Faria⁴ 

[1] Comprehensive Pain Center, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Fetscherstraße 74, 01307, Dresden, Germany;Department of Basic Neurosciences, University of Geneva, CH-1211, Geneva 4, Switzerland;CIBM Center for Biomedical Imaging, 1015, Lausanne, Switzerland;Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Smell & Taste Clinic, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany;Department of Otorhinolaryngology, Faculty of Medicine Carl Gustav Carus, Smell & Taste Clinic, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany;Department of Psychology, Uppsala University, 752 37, Uppsala, Sweden;Brain and Eye Pain Imaging Lab, Pain and Affective Neuroscience Center, Boston Children’s Hospital, Harvard Medical School, MA 02115, Boston, MA, USA;Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Harvard Medical School, MA 02115, Boston, MA, USA;

关键词: Migraine;    Aura;    Olfaction;    Trigeminal;    EEG;   

DOI  :  10.1186/s10194-023-01592-3

 received in 2023-03-13, accepted in 2023-05-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundAccumulating data emphasizes the importance of olfaction in migraine pathophysiology. However, there are only a few studies evaluating how the migraine brain processes olfactory stimulation, and virtually no studies comparing patients with and without aura in this context.MethodsThis cross-sectional study recorded event-related potentials from 64 electrodes during a pure olfactory or pure trigeminal stimulus in females with episodic migraine with aura (n = 13) and without aura (n = 15), to characterize the central nervous processing of these intranasal stimuli. Patients were tested in interictal state only. Data were analyzed in the time domain and in the time–frequency domain. Source reconstruction analysis was also performed.ResultsPatients with aura had higher event-related potentials amplitudes for left-sided trigeminal and left-sided olfactory stimulations, and higher neural activity for right-sided trigeminal stimulation in brain areas related to trigeminal and visual processing. Following olfactory stimulations patients with aura displayed decreased neural activity in secondary olfactory structures compared to patients without aura. Oscillations in the low frequency bands (< 8 Hz) differed between patient groups.ConclusionsAltogether this may reflect hypersensitivity to nociceptive stimuli in patients with aura relative to patients without aura. Patients with aura have a bigger deficit in engaging secondary olfactory-related structures, possibly leading to distorted attention and judgements towards odors. The cerebral overlap between trigeminal nociception and olfaction might explain these deficits.

【 授权许可】

CC BY   
© The Author(s) 2023

【 图 表 】

41116_2023_36_Article_IEq684.gif

41116_2023_36_Article_IEq655.gif

41116_2023_36_Article_IEq653.gif

41116_2023_36_Article_IEq649.gif

41116_2023_36_Article_IEq644.gif

41116_2023_36_Article_IEq493.gif