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Clinical Epigenetics
The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures
Review
Rosalia Battaglia1  Cinzia Di Pietro1  Maria Rosaria Campitiello2  Giulia Sgueglia3  Lucia Altucci4  Carmela Dell’Aversana5  Thomas D’Hooghe6  Salvatore Longobardi6  Domenico Valerio7  Nicola Colacurci8 
[1] Department of Biomedical and Biotechnological Sciences, Section of Biology and Genetics “Giovanni Sichel”, University of Catania, 95123, Catania, CT, Italy;Department of Obstetrics and Gynecology and Physiopathology of Human Reproduction, ASL Salerno, Salerno, Italy;Department of Precision Medicine, University of Campania ‘Luigi Vanvitelli’, Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy;Department of Precision Medicine, University of Campania ‘Luigi Vanvitelli’, Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy;BIOGEM, Ariano Irpino, Italy;Institute of Experimental Endocrinology and Oncology ‘Gaetano Salvatore’ (IEOS)-National Research Council (CNR), Naples, Italy;Department of Precision Medicine, University of Campania ‘Luigi Vanvitelli’, Programma di Epigenetica Medica, Azienda Ospedaliera Universitaria, Naples, Italy;Institute of Experimental Endocrinology and Oncology ‘Gaetano Salvatore’ (IEOS)-National Research Council (CNR), Naples, Italy;Merck KGaA, 64293, Darmstadt, Germany;Outpatient Fertility Unit, University of Campania ‘Luigi Vanvitelli’, 80138, Naples, Italy;Outpatient Fertility Unit, University of Campania ‘Luigi Vanvitelli’, 80138, Naples, Italy;Department of Woman, Child and General and Special Surgery, University of Campania ‘Luigi Vanvitelli’, 80138, Naples, Italy;
关键词: Epigenetics;    Fertility;    IVF;    Reproduction;   
DOI  :  10.1186/s13148-023-01490-0
 received in 2023-02-28, accepted in 2023-04-24,  发布年份 2023
来源: Springer
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【 摘 要 】

The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success.Graphical Abstract

【 授权许可】

CC BY   
© The Author(s) 2023

【 预 览 】
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