Temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019

BMC Geriatrics

Research

Floor J. A. van Deudekom¹  Estelle van Eijk²  Frederiek van den Bos²  Yanna M. van der Spek²  Stella Trompet³  Simon P. Mooijaart³ 

[1] Department of Geriatrics, OLVG, Amsterdam, The Netherlands;Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands;Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands;LUMC Center for Medicine for Older People, Leiden, The Netherlands;

关键词: Geriatric assessments;    Temporal changes;    Older individuals;    Systematic review;    Randomized controlled trials;   

DOI  :  10.1186/s12877-023-04018-6

 received in 2022-10-05, accepted in 2023-05-04,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundOlder individuals are often underrepresented in clinical trials. In 2012 only 7% of RCT’s specifically studied older people and their geriatric characteristics were poorly reported. The aim of this review was to investigate temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019.MethodsPubMed was searched for randomized clinical trials (RCTs) published in 2019. Firstly, the proportion of RCTs specially designed for older people were determined by the following criteria: a reported mean age of ≥ 70 years or a lower age cutoff of ≥ 55. Secondly, the trials with a majority of older people, defined by a reported mean age of ≥ 60 years, were screened for reporting of geriatric assessments. Both parts were compared with identical reviews performed in 2012.ResultsFrom a 10% random sample, 1446 RCTs were included in this systematic review. First, 8% of trials were specifically designed for older people in 2019 compared to 7% in 2012. Secondly, 25% of the trials included a majority of older people in 2019, compared to 22% in 2012. Thirdly, in 52% of these trials in 2019 one or more of the geriatric assessments were reported compared to 34% in 2012.ConclusionsAlthough in 2019 the proportion of published RCTs specifically designed for older people remains low, more characteristics on geriatric assessments were reported compared to 2012. Continued efforts should be paid to increase both the number and the validity of trials for older people.

【 授权许可】

CC BY   
© The Author(s) 2023

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