Preliminary validation of a brief PROM assessing psychological distress in patients with malignant mesothelioma: The mesothelioma psychological distress tool—Patients

Frontiers in Psychology

article

Fanny Guglielmucci¹  Michela Bonafede²  Danila Azzolina³  Alessandro Marinaccio²  Isabella Giulia Franzoi⁴  Enrica Migliore⁵  Carolina Mensi⁶  Elisabetta Chellini⁷  Elisa Romeo⁸  Federica Grosso⁹  Antonella Granieri⁴ 

[1] Department of Philosophy, Communication and Performing Arts, University of Roma Tre;Occupational and Environmental Medicine, Epidemiology and Hygiene Department;Department of Environmental and Preventive Sciences, University of Ferrara;Department of Psychology, University of Turin;COR Piedmont, Unit of Cancer Epidemiology, University of Turin and CPO-Piedmont;COR Lombardy, Epidemiology Unit, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico and University of Milan;COR Tuscany, Cancer Prevention and Research Institute;COR Lazio, Department of Epidemiology, Lazio Regional Health Service;Mesothelioma Unit, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo

关键词: Asbestos;    Cancer;    Mental Health;    Mesothelioma;    Patient-reported outcome measures;    psychological distress;    Psycho-oncology;    posttraumatic stress disorder;   

DOI  :  10.3389/fpsyg.2022.974982

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Objective: Psychological suffering in malignant mesothelioma (MM) differs from that in other cancers because of its occupational etiology, and we aimed to develop specific patient-reported outcome measures (PROMs) to assess it. Methods: We used a multi-method prospective observational multicentric study (N=149), and a preliminary questionnaire validation was performed through a Bayesian approach.. Results: Item analysis showed a good internal consistency and reliability (Cronbach alpha = 0.79 [95% CI=0.74-0.93]. Twenty of the 41 initial items were selected as posterior 95% highest density interval (HDI) factor loading standardized effect size fell outside of the region of practical equivalence (ROPE). Bayesian exploratory factor analysis (BEFA) showed a two-factor structure: 1) Trauma-related reactions (TR, 13 items) and 2) Claim for justice (CJ, 7 items), confirmed by the Bayesian confirmatory factor analysis (BCFA). Latent factors were poorly correlated (Posterior median: 0.13; 95% CI=-0.079–0.323). The 90% root mean square error of approximation (RMSEA) posterior median was 0.04 [90% CI = 0.03–0.58]; the 90% Chi-square posterior median was 242 [90% CI = 209–287]. Conclusions: Psychological suffering in MM patients implies negative cognitive, emotional, and somatic reactions related to the traumatic impact of the disease and the need to obtain justice through economic compensation. Our findings provide preliminary evidence that the Mesothelioma Psychological Distress Tool-Patients (MPDT-P) could be a promising and reliable instrument to assess MM patients’ psychological distress.

【 授权许可】

CC BY