Exploring the effect of Radix Bupleuri ( Bupleurum chinense DC) on nonalcoholic fatty liver disease based on network pharmacology

TMR Integrative Medicine

article

Xu He¹  Ye Jiang²  Kui Wang³ 

[1] Guangdong Provincial Center of Integrated Traditional Chinese and Western Medicine for Metabolic Diseases, Guangdong Pharmaceutical University;Department of Acupuncture and Rehabilitation, Wuyuan County People’s Hospital;Department of Cardiology, Jingdezhen Traditional Chinese Medicine Hospital

关键词: network pharmacology;    Radix Bupleuri;    nonalcoholic fatty liver disease;    traditional Chinese medicine;   

DOI  :  10.53388/TMRIM202206016

学科分类：医学（综合）

来源: TMR publishing group

【 摘 要 】

Objective: To investigate the main effects of Radix Bupleuri (Chinese name called Chai Hu)in the prevention and improvement of nonalcoholic fatty liver disease using networkpharmacology techniques. Methods: We used the Traditional Chinese Medicine SystematicPharmacology database to query the main active ingredients of Radix Bupleuri; used theDisGenet database, Treatment Target Database, and DrugBank Database to screen thetargets of nonalcoholic fatty liver disease; used the matching traditional Chinesemedicine-disease targets to build the traditional Chinese medicine-component-targetnetwork system using Cytoscape software; used STRING software to build the proteinprotein interaction system and visualized the data; DAVID database was used for geneontology functional enrichment study and Kyoto Encyclopedia of Genes and Genomespathway study. Results: Twelve major functional components and 175 targets have beenobtained for the prevention and alleviation of nonalcoholic fatty liver disease in RadixBupleuri; network pharmacology also confirmed the maximum degree value of kaempferol,the main active component of Radix Bupleuri; gene ontology functional enrichment analysisobtained the top 10 entries of biological process, cellular component, molecular functionand Kyoto Encyclopedia of Genes and Genomes pathway analysis obtained the top 30 entriesof the signalling pathway. Conclusion: Radix Bupleuri may use Fluid shear stress andatherosclerosis, Cancer, Advanced glycation end-(receptor of advanced glycation,interleukin 17, Hepatitis B, Toxoplasmosis, Relaxin, and tumor necrosis factor signallingpathway to regulate the inflammatory response of interleukin 6, tumor necrosis factor, andprostaglandin endoperoxide synthase2 targets and reduce extracellular matrix deposition toimprove the therapeutic effect of Nonalcoholic fatty liver disease. And the active ingredientof traditional Chinese medicine Radix Bupleuri, kaempferol, may also play a significant rolein this.

【 授权许可】

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