Effectiveness and safety of acupuncture on cancer pain: a meta-analysis

TMR Integrative Medicine

article

Xian-Bing Hou¹  Dan-Dan Chen¹ 

[1] Fenghua Hospital of Traditional Chinese Medicine

关键词: Acupuncture;    Opioid;    Eruption pain frequency;    Analgesia duration;    Cancer pain;    Meta-analysis;   

DOI  :  10.12032/TMRIM202004019

学科分类：医学（综合）

来源: TMR publishing group

【 摘 要 】

Objective: The aim of the study was to evaluate the efficacy of acupuncture combined with opiates in the treatmentof cancer pain through the meta-analysis system. Methods: China national knowledge infrastructure and VIPDatabase for Chinese technical periodicals, China Biology Medicine, PubMed, Embase databases were searchedfrom January 2016 to February 8, 2020 for the randomized controlled trials on the effects of acupuncture combinedwith opiates on cancer pain. Meta-analysis of ordered data was performed using Stata-MP64 and Review Manager5.3 software. Results: A total of 242 Chinese studies and 25 English studies were retrieved. According to theinclusion and exclusion criteria, 19 literatures finally were included. The fixed effect model was used to combinethe total effect values, and the combined odds ratio (OR) (95% confidence interval (CI)) was 2.981 (2.384, 3.729), suggesting that acupuncture combined with opiates was better than opiates alone in treating cancer pain (Z = 9.57, P < 0.05); the combination treatment could improve Karnofsky Performance Status score (Z = 2.48, P = 0.01), decrease Numerical Rating Scale score (Z = 2.89, P = 0.004); it also could reduce eruption pain frequency (Z = 4.32, P < 0.0001), improve the effects time (Z = 2.51, P = 0.01), and extend analgesia duration (Z = 4.33, P < 0.0001);the combination group also had lower Oxycodone dose than the control group (Z = 3.193, P = 0.001). At the sametime, the incidence of adverse reactions was lower than that of the opiate treatment group alone, with a OR (95%CI) of 0.27 (0.19, 0.37) and statistical significance, Z = 8.06, P < 0.05. Conclusion: Acupuncture combined withopioids for cancer pain is superior to opioids alone with a lower incidence of adverse reactions.

【 授权许可】

CC BY