Can Chinese herbal medicine improve the pregnancy outcomes of patients with poor ovarian response? —a systematic review and meta-analysis of randomized controlled trials

TMR Integrative Medicine

article

Di Lu¹  Shu-Yong Zhang²  Dian-Rong Song¹ 

[1] Department of Gynecology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine;Clinical Laboratory Center, 302 Hospital of PLA

关键词: Chinese herb medicine;    Poor ovarian response;    Pregnancy rate;    Meta-analysis.;   

DOI  :  10.12032/TMRIM201903019

学科分类：医学（综合）

来源: TMR publishing group

【 摘 要 】

Poor response to ovarian stimulation which results in low pregnancy rate has been a major challenging inassisted reproductive technology. Chinese herbal medicine (CHM) has been used as a supplementary or an alternative intervention in improving pregnancy rate in women with poor ovarian response (POR). Thissystematic review was aimed to assess the clinical effectiveness of Chinese herbal medicine for thetreatment of POR. We searched Embase, PubMed, China National Knowledge Infrastructure (CNKI), VIPDatabase, Chinese biomedical database (CBM), Wan Fang database and the Cochrane library fromJanuary 2011 to March 2018. Study quality assessment and meta­analyses were performed according tothe Cochrane recommendations. 16 trials including 1245 ovulation-promoting cycles were evaluated. Theanalysis showed that CHM can increase the pregnancy rate (RR = 1.80, 95% CI (1.41-2.29), P < 0.001), while decrease cycle cancellation (RR= 0.66, 95% CI (0.45-0.97), P = 0.04). Conclusion: CHM presented a promising effectiveness in women with POR as a supplementary or an alternative intervention in IVF/ICSI.

【 授权许可】

CC BY