Angiotensin converting enzyme inhibitory effect of Medicago sativa root extract

International Journal of ChemTech Research

article

Pandya Devang J¹  Savalia Vaibhavi B¹ 

[1] School of Pharmacy, RK University

关键词: Hypertension;    Alfalfa;    Angiotensin converting enzyme;    Medicago sativa;   

DOI  :  10.20902/IJCTR.2018.110217

学科分类：农业科学（综合）

来源: Sphinx Knowledge House

【 摘 要 】

Angiotensin-converting enzyme plays an important role in treatment ofhypertension. The purpose of present study is to estimate in vitro(angiotensin convertingenzyme) ACE inhibitory activity of Medicago sativa Linn.Root. The ability to inhibit ACEwas measured by direct spectrophotometric method. ACE inhibitory study was evaluated byusing Lisinopril as standard. Extract were prepared by successive maceration with toluene,chloroform, methanol and water. Among all extract tested of root methanol extract showed themaximum and dose dependent ACE inhibitory activity at IC50 value of 34.43±0.31 µg/mlconcentration. Standard Lisinopril possess inhibition of ACE at IC50 value of0.2599±0.02ng/ml. Present study shows root methanol extract of Medicago sativa as potentialACE inhibitor. Medicago sativa can further explored for active constituent responsible forACE inhibitory activity.

【 授权许可】

CC BY