Synthesis, In Vitro Antioxidant and Antimicrobial Evaluation of 3-Hydroxy Chromone Derivatives

International Journal of ChemTech Research

article

Pallavi Kamble¹  Sailesh Wadher¹ 

[1] School of Pharmacy, Swami Ramanand Teerth Marathwada University

关键词: Chromone;    Chalcone;    Claisen-Schmidt condensation;    Algar Flynn Oyamadamethod;    Antioxidant;    Antibacterial;    Antifungal;   

DOI  :  10.20902/IJCTR.2018.110209

学科分类：农业科学（综合）

来源: Sphinx Knowledge House

【 摘 要 】

3-hydroxy chromones were synthesized by Algar Flynn Oyamada method whichincludes oxidative cyclization of 2-hydroxy chalcones in basic solution by hydrogen peroxide.Chalcones required were synthesized by Claisen-Schmidt condensation of substituted 2-hydroxy acetophenones with substituted aromatic aldehydes using PEG-400 as recyclablesolvent. The synthesized compounds were evaluated for in vitro antioxidant activity by 1,1-diphenyl-2-pycrylhydrazyl radical scavenging assay. Additionally, these compounds were alsoscreened for in vitro antibacterial and antifungal activity by agar cup method and Poison platemethod, respectively. The structures of the synthesized compounds were characterized by IR,1H NMR and Mass spectra. The antioxidant activity data revealed that all the synthesizedderivatives of chromone showed greater antioxidant activity due to presence of phenolichydroxyl group, 4-oxo group and 2,3-double bond. Further the activity increased withintroduction of more phenolic hydroxyl group and adjacent methoxy group in the structure.The antimicrobial activity data showed that the compounds exhibited good antibacterial andantifungal activity which is attributed to the presence of phenolic hydroxyl group and 4-oxogroup in the structure.

【 授权许可】

CC BY