Study of liver X receptor-alpha gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients

Journal of the Egyptian Women s Dermatologic Society

article

Alsayeda Alsayed Ahmad Taha¹  Nagat Sobhy Mohamed¹  Eman Tayae Alsayed²  Amany Gamal AbdelAziz Ahmed¹ 

[1] Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University;Department of Clinical Pathology, Faculty of Medicine, Alexandria University

关键词: gene polymorphism;    liver X receptor alpha;    vitiligo;   

DOI  :  10.4103/jewd.jewd_68_21

学科分类：皮肤病学

来源: Egyptian Women s Dermatological Society

【 摘 要 】

Background  Vitiligo is an acquired skin disorder that results from selective destruction of skin melanocytes. It is characterized clinically by the development of depigmented macules and patches. More than 150 genes have been identified to affect the pigmentation of the skin, hair, and eyes. Liver X receptor-α (LXR-α) expression is upregulated in the melanocytes of the perilesional skin as compared with the normal skin of vitiligo patients suggesting its possible contribution in vitiligo pathogenesis. Objective  To study LXR-α gene polymorphism (rs2279238) in a sample of Egyptian vitiligo patients. Patients and methods  T) detection was done by allelic discrimination using fluorogenic 5’ Nuclease assay. Results  LXR-α gene polymorphism was significantly associated with vitiligo among Egyptian patients but is not correlated with either severity or activity of vitiligo. Conclusion  LXR-α gene polymorphism may be associated with vitiligo as found in a sample of Egyptian patients.

【 授权许可】

CC BY