Remission Rate of Acute Lymphoblastic Leukemia (ALL) in Adolescents and Young Adults (AYA)

Journal of the College of Physicians and Surgeons Pakistan

article

Anita Vallacha¹  Ghulam Haider¹  Wiky Raja¹  Dinesh Kumar¹ 

[1] Department of Oncology, Jinnah Postgraduate Medical Center

关键词: Remission;    Acute lymphoblastic leukemia;    Adolescents;    Young adults;   

学科分类：医学（综合）

来源: College of Physicians and Surgeons Pakistan. Journal

【 摘 要 】

Objective: To determine the remission rate in adolescent and young adult (AYA) patients with acute lymphoblasticleukemia (ALL).Study Design: Descriptive study.Place and Duration of Study: Department of Oncology, Jinnah Postgraduate Medical Centre (JPMC), Karachi fromJanuary, 2016 to March, 2017.Methodology: Adolescent and young adult (AYA) patients aged 15-39 years, newly diagnosed with acute lymphoblasticleukemia from January, 2016 to March, 2017. Diagnosis was confirmed by bone marrow trephine biopsy and immunophenotyping. All the patients were treated with daunorubicin, vincristine, prednisone, and L-asparaginase in the inductionphase. The response evaluation was done on day 35 of the induction phase and the remission rate was assessed by thebone marrow examination.Results: Of the total 50 AYA patients diagnosed with ALL, 41 patients could complete induction phase and 9 patients diedduring the first week of induction, therefore excluded from the study. Forty (97.8%) patients were <35years of age,28 (68.3%) were male, of female 10 (24.4%) were housewives, 33 (80.5%) patients belonged to Sindh, 28 (68.3%)presented with fever and body ache, 17 (41.5%) patients had precursor B cell type ALL, with 7 (17.1%) patients hadhemoglobin of <7 g/dL,11 (26.8%) patients had white cell count of >30x109/L, platelet count of <20x103/µL in 6 (14.6%)patients and complete morphological remission was reported in 29 (70.7%) patients.Conclusion: The remission induction rate was 70.7% in the adolescents and young adults with acute lymphoblasticleukemia at the study centre.

【 授权许可】

CC BY