Transdermal buprenorphine for pain management in children

Drugs in Context

article

Giorgio Attin๠ Alberto Romano¹  Silvia Triarico¹  Stefano Mastrangelo¹  Palma Maurizi¹  Antonio Ruggiero¹ 

[1] Pediatric Oncology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS;Università Cattolica Sacro Cuore

关键词: buprenorphine;    children;    opioids;    pain;    transdermal;   

DOI  :  10.7573/dic.2021-6-1

学科分类：社会科学、人文和艺术（综合）

来源: C S F Medical Communications Ltd.

【 摘 要 】

Pain is one of the main symptoms reported by sick children, particularly by those suffering from cancer. Opioids are very useful in controlling this symptom but they are burdened with significant side effects that limit their use in children. Buprenorphine is a strong opioid that, due to its particular pharmacological characteristics, ensures excellent pain relief with fewer side effects than other opioids. The transdermal formulation allows for good pain control associated with optimal compliance by patients and few limitations on daily life. Unfortunately, transdermal buprenorphine use remains off-label for the control of chronic pain in children; therefore, it is desirable that new studies can validate its use in the paediatric population. This review aims to analyse the clinical advantages of transdermal buprenorphine in the paediatric population and the possible side effects registered in daily clinical practice.

【 授权许可】

CC BY-NC-ND