Paediatrics: how to manage septic shock

Drugs in Context

article

Felix Oberender¹  Kam Lun Hon³  Karen Ka Yan Leung³  Alexander KC Leung⁴ 

[1] Paediatric Intensive Care Unit, Monash Children’s Hospital;Monash University, School of Clinical Sciences, Department of Paediatrics;Paediatric Intensive Care Unit, Department of Paediatrics and Adolescent Medicine, Hong Kong Children’s Hospital;Department of Pediatrics, University of Calgary and Alberta Children’s Hospital

关键词: antibiotics;    critical care;    inotropes;    intensive care;    lactate;    organ dysfunction;    paediatrics;    sepsis;    septic shock;    systemic inflammatory response syndrome;   

DOI  :  10.7573/dic.2021-1-5

学科分类：社会科学、人文和艺术（综合）

来源: C S F Medical Communications Ltd.

【 摘 要 】

Background: Septic shock is a common critical illness associated with high morbidity and mortality in children. This article provides an updated narrative review on the management of septic shock in paediatric practice. Methods: A PubMed search was performed using the following Medical Subject Headings: “sepsis”, “septic shock” and “systemic inflammatory response syndrome”. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies and reviews. The search was limited to the English literature and specific to children. Results: Septic shock is associated with high mortality and morbidity. The outcome can be improved if the diagnosis is made promptly and treatment initiated without delay. Early treatment with antimicrobial therapy, fluid therapy and vasoactive medications, and rapid recognition of the source of sepsis and control are the key recommendations from paediatric sepsis management guidelines. Conclusion: Most of the current paediatric sepsis guideline recommendations are based on the adult population; therefore, the research gaps in paediatric sepsis management should be addressed.

【 授权许可】

CC BY-NC-ND