Drugs in Context | |
TAS-102 in metastatic colorectal cancer (mCRC): efficacy, tolerability, and quality of life in heavily pretreated elderly patients: a real-life study | |
article | |
Giuseppe Cicero1  Raffaele Addeo2  Rossella De Luca1  Giuseppe Lo Re4  Leonardo Gulotta4  Pierenrico Marchesa5  Gaspare Gulotta4  | |
[1] Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo;Oncology Unit;3Department of Radiology, University of Palermo;Department of Surgical, Oncological and Oral Sciences, Section of General and Emergency Surgery, University of Palermo;ARNAS Hospital Civico | |
关键词: chemotherapy; elderly patients; Lonsurf; metastatic colorectal cancer; quality of life; TAS-102; trifluridine/tipiracil; | |
DOI : 10.7573/dic.2020-6-3 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: C S F Medical Communications Ltd. | |
【 摘 要 】
Background: TAS-102 is an oral monotherapy, combining trifluridine and tipiracil hydrochloride, indicated for the treatment of pretreated metastatic colorectal cancer (mCRC). The aim of this real-life study is to evaluate the efficacy and safety of TAS-102 in heavily pretreated elderly patients with mCRC whose disease has progressed with standard therapies. Methods:70 years with advanced colorectal cancer and with an ECOG performance status of grade 0 (n=18) or grade 1 (n=32) were included. Overall survival and progression-free survival were the primary endpoints, whereas objective response rate, tolerability, and quality of life were the secondary endpoints. Results: Treatment with TAS-102 appeared to be well tolerated and side effects were generally mild, achieving disease control and a benefit on quality of life. The median overall survival was 6.7 (95% CI 5.7–11.3) and the median progression-free survival was 2.1 months (95% CI 1.2–3.2), estimated using the Kaplan– Meier method. Conclusion: TAS-102 represents a manageable and effective therapeutic opportunity and appeared to be well tolerated with generally mild side effects in elderly patients with mCRC who were heavily pretreated with standard therapies.
【 授权许可】
CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
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RO202307150001613ZK.pdf | 368KB | download |