TAS-102 in metastatic colorectal cancer (mCRC): efficacy, tolerability, and quality of life in heavily pretreated elderly patients: a real-life study

Drugs in Context

article

Giuseppe Cicero¹  Raffaele Addeo²  Rossella De Luca¹  Giuseppe Lo Re⁴  Leonardo Gulotta⁴  Pierenrico Marchesa⁵  Gaspare Gulotta⁴ 

[1] Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo;Oncology Unit;3Department of Radiology, University of Palermo;Department of Surgical, Oncological and Oral Sciences, Section of General and Emergency Surgery, University of Palermo;ARNAS Hospital Civico

关键词: chemotherapy;    elderly patients;    Lonsurf;    metastatic colorectal cancer;    quality of life;    TAS-102;    trifluridine/tipiracil;   

DOI  :  10.7573/dic.2020-6-3

学科分类：社会科学、人文和艺术（综合）

来源: C S F Medical Communications Ltd.

【 摘 要 】

Background: TAS-102 is an oral monotherapy, combining trifluridine and tipiracil hydrochloride, indicated for the treatment of pretreated metastatic colorectal cancer (mCRC). The aim of this real-life study is to evaluate the efficacy and safety of TAS-102 in heavily pretreated elderly patients with mCRC whose disease has progressed with standard therapies. Methods:70 years with advanced colorectal cancer and with an ECOG performance status of grade 0 (n=18) or grade 1 (n=32) were included. Overall survival and progression-free survival were the primary endpoints, whereas objective response rate, tolerability, and quality of life were the secondary endpoints. Results: Treatment with TAS-102 appeared to be well tolerated and side effects were generally mild, achieving disease control and a benefit on quality of life. The median overall survival was 6.7 (95% CI 5.7–11.3) and the median progression-free survival was 2.1 months (95% CI 1.2–3.2), estimated using the Kaplan– Meier method. Conclusion: TAS-102 represents a manageable and effective therapeutic opportunity and appeared to be well tolerated with generally mild side effects in elderly patients with mCRC who were heavily pretreated with standard therapies.

【 授权许可】

CC BY-NC-ND