Tensor Domain Averaging in Diffusion Imaging of Small Animals to Generate Reliable Tractography

ParadigmPlus

article

Juan Yepes Zuluaga¹  Fernando Yepes-Calderon² 

[1] Science Based Platforms;GYM Group SA

关键词: Neurodegenerative Diseases;    Small Animal MRI;    Animal Models;    Diffusion Tensor Imaging;    Image Enhancement;   

DOI  :  10.55969/paradigmplus.v2n1a1

学科分类：环境工程

来源: ITI Research Group

【 摘 要 】

Testing on small animal models is roughly the only path to transfer science-based knowledgeto human use. More avidly than other human organs, we study the brain through animal modelsdue to the complexity of experimenting directly on human subjects, even at a cellular level wherethe skull makes tissue sampling harder than in any other organ. Thanks to recent technologicaladvances in imaging, animals do not need to be sacrificed. Magnetic resonance, in particular, favors long-term analysis and monitoring since its methods do not perturb the organ functions norcompromise the metabolism of the animals. Neurons’ integrity is now indirectly visible under specialized mechanisms that use water displacement to track static boundaries. Although these waterdiffusion methods have proven to be successful in detecting neuronal structure at the submillimeterscale, they yield noisy results when applied to the resolutions required by small animals or whenfacing low myeline contents as in neonates and young children. This manuscript presents a strategyto display neuronal trending representations that follow the corticospinal tract’s pathway and neuronal integrity in small rodents. The strategy is the foundation to study human neurodegenerativediseases and neurodevelopment as well.

【 授权许可】

CC BY