Modeling and molecular dynamics simulations yield insights into channel malfunction

Journal of Applied & Computational Mathematics

article

Phili Charles Bigin¹ 

[1] Department of Biochemistry, University of oxford

关键词: molecular dynamics;   

DOI  :  10.37421/2168-9679.2021.10.490

来源: Hilaris Publisher

【 摘 要 】

Channelopathies area unit outlined as sickness states wherever the firstcause could be a dysfunctional particle channel and embrace conditionslike brain disease, pain syndromes, pancreatic fibrosis, viscous arrhythmias,tonus and lots of others Many of those conditions is attributed to mutationsthat result in alteration of particle channel perform in some wayf we have atendency to area unit to be able to supply some quite drug-based treatmentfor these conditions within the future, a whole molecular understanding ofthe consequences of the mutations can offer the foremost rational footingfrom that to proceed. several single ester polymorphisms (SNPs) related todiseases of particle channel perform area unit fatal, for instance whereverthe mutation means the channel or auxiliary supermolecule can merely noteven get expressed or properly trafficked to the suitable membrane Evenwith the structure in hand there's still the matter that particle channels bydefinition area unit terribly dynamic entities.

【 授权许可】

Unknown