Model Tumor Pattern and Compare Treatment Effects Using Semiparametric Linear Mixed-Effects Models

Journal of Biometrics & Biostatistics

article

Changming Xia¹  Jianrong Wu²  Hua Liang¹ 

[1] Department of Biostatistics and Computational Biology, University of Rochester Medical Center;Department of Biostatistics, St Jude Children’s Research Hospital

关键词: Antitumor xenograft model;    Cubic splines;    Longitudinal analysis;    Semiparametric models;    Smoothing spline ANOVA;   

DOI  :  10.4172/2155-6180.1000168

来源: Hilaris Publisher

【 摘 要 】

To analyze responses of solid tumor to treatments and to compare treatment effects with antitumor therapies, we applied semiparametric mixed-effects models to fit tumor volumes measured over a period. The population and individual nonparametric functions were approximated by smoothing spline. We also proposed an intuitive method for a comparison of the antitumor effects of two different treatments. Biological interpretation was also discussed.

【 授权许可】

Unknown