Chemical Reactions of Indole Alkaloids That Enable Rapid Access to New Scaffolds for Discovery

SynOpen

article

Derek A. Leas¹  Daniel C. Schultz¹  Robert W. Huigens III¹ 

[1] Department of Medicinal Chemistry, Center for Natural Products Drug Discovery and Development ,(CNPD3), College of Pharmacy, University of Florida, 1345 Center Drive

关键词: indole alkaloids;    yohimbine;    vincamine;    reserpine;    chemical synthesis;    ring distortion;   

DOI  :  10.1055/a-2048-8412

学科分类：精神健康和精神病学

来源: Thieme

【 摘 要 】

This graphical review provides a concise overview of indole alkaloids and chemical reactions that have been reported to transform both these natural products and derivatives to rapidly access new molecular scaffolds. Select biologically active compounds from these synthetic efforts are reported herein.

【 授权许可】

CC BY|CC BY-NC-ND