Red-Shifting Blue Light Photoredox Catalysis for Organic Synthesis: A Graphical Review

SynOpen

article

Logan R. Beck¹  Katherine A. Xie¹  Samantha L. Goldschmid¹  Stavros K. Kariofillis¹  Candice L. Joe²  Trevor C. Sherwood³  Melda Sezen-Edmonds²  Tomislav Rovis¹ 

[1] Department of Chemistry, Columbia University;Chemical Process Development, Bristol Myers Squibb;Small Molecule Drug Discovery, Bristol Myers Squibb

关键词: photoredox catalysis;    deep red and near-infrared light;    cross-coupling;    reaction engineering;    photodynamic therapy;    photoaffinity labeling;    proximity labeling;    multiphoton excitation;   

DOI  :  10.1055/s-0040-1720060

学科分类：精神健康和精神病学

来源: Thieme

【 摘 要 】

Photoredox catalysis has revolutionized synthetic chemistry in recent decades. However, the field has traditionally used high-energy blue/ultraviolet light to activate chromophores. High-energy irradiation is associated with several drawbacks (e.g., activation of sensitive functional groups, undesired metal-ligand homolysis, background activation of molecules, and poor penetration), which has led researchers to develop alternative systems with lower energy deep red (DR) or near-infrared (NIR) light. This graphical review provides a concise overview of photophysical principles relevant to photoredox catalysis. Several applications that benefit from low-energy irradiation, such as large-scale batch reactions, photodynamic therapy, biological labeling, and multi-photon excitation are reviewed.

【 授权许可】

CC BY|CC BY-NC-ND