Synthesis of α-Sulfoximino Tetrazoles via Azido-Ugi Four-Component Reaction

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C. P. Irfana Jesin¹  Ramesh Kataria²  Ganesh Chandra Nandi¹ 

[1] Department of Chemistry, National Institute of Technology;Department of Chemistry & Centre for Advanced Studies in Chemistry, Panjab University

关键词: sulfoximines;    sulfonimidamides;    Ugi reaction;    tetrazoles;    isocyanides;   

DOI  :  10.1055/a-1981-9151

学科分类：精神健康和精神病学

来源: Thieme

【 摘 要 】

The sulfoximine-based tetrazoles have been synthesized via azido-Ugi four-component reactions of sulfoximines, isocyanides, aldehydes, and TMS-azide in MeOH at 70 °C in the presence of InCl3. Replacement of sulfoximines with sulfonimidamides (SIA) has delivered the corresponding SIA-based tetrazole. Interestingly, SIA also acts as a surrogate amine to furnish the corresponding aminotetrazole as a by-product.

【 授权许可】

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