期刊论文详细信息
Urología Colombiana | |
Experiencia con el uso de toxina botulínica en niños con vejiga hiperactiva neurogénica: Una serie de casos | |
article | |
Andrea Bolaños1  Carlos Larios1  Anamaria Ramos Hernandez1  Byron Eduardo López de Mesa Rodríguez2  Sara Rocío Peralta3  Luisa Noreña4  | |
[1]Hospital Universitario San José Infantil | |
[2]Fundación Universitaria de Ciencias de la Salud, Hospital Universitario José infantil | |
[3]Fundación Universitaria Sanitas | |
[4]Departamento de Urologia | |
关键词: detrusor hiperactivo neruogénico; toxina botulínica tipo A; niños; vejiga; incontinencia urinaria; mielomeningocele; | |
DOI : 10.1055/s-0042-1758464 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Thieme | |
![]() |
【 摘 要 】
Objective To describe the experience with the administration of botulinum toxin injection in children with neurogenic overactive bladder who were refractory to the first-line management.Materials and Methods A descriptive observational study (case series) which included 14 children with a diagnosis of neurogenic overactive bladder who were refractory to the first-line treatment and were aubmitted to the intravesical administration of botulinum toxin between 2015 and 2021. Follow-up was performed taking into account the clinical variables, wth an evaluation of the response and the adverse events. Absolute frequencies and percentages were reported for the qualitative variables; for the quantitative variables, measures of central tendency and dispersion were reported.Results We included 6 boys and 8 girls with a mean age of 10.1 (standard deviation [SD]: ± 4.4) years. All patients were previously treated with anticholinergics and clean intermittent catheterizations, with a mean use of 2.8 (SD: ± 1.0) diapers per day; 11 (78.5%) had a history of urinary tract infection, 13 (92.8%), constipation, and 2 (15.3%), fecal incontinence. On ultrasound, 7 (50.0%) patients presented bladder wall thickening, and 6 (42.8%), hydronephrosis. After the procedure, 1 patient presented urinary tract infection as a complication, 6 presented complete response, 7, partial response, and 1 patient did not obtain a response with the first injection, with an effective mean time of therapy of 8 (SD: ± 6.3) months. A second injection was required by 6 (42.8%) patients, and of these, 3 (50%) required a third injection.Conclusion Intravesical botulinum toxin injection as a second-line management therapy for neurogenic overactive bladder yileds good results, with low rates of complications.【 授权许可】
CC BY|CC BY-NC-ND
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202307130003254ZK.pdf | 445KB | ![]() |