FAIR data in meta-omics research: Using the MOD-CO schema to describe structural and operational elements of workflows from field to publication

Biodiversity Information Science and Standards

article

Janno Harjes¹  Dagmar Triebel²  Anton Link²  Tanja Weibulat³  Frank Oliver Glöckner⁴  Gerhard Rambold¹ 

[1] University of Bayreuth;Staatliche Naturwissenschaftliche Sammlungen Bayerns;German Federation for Biological Data e.V.;Alfred-Wegener-Institut

关键词: collection data;    conceptual schema;    DiversityDescriptions;    LIMS;    meta-omics;    workflow segments;   

DOI  :  10.3897/biss.3.37596

来源: Pensoft

【 摘 要 】

Nucleic acid and protein sequencing-based analyses are increasingly applied to determine origin, identity and traits of environmental (biological) objects and organisms. In this context, the need for corresponding data structures has become evident. As existing schemas and community standards in the domains of biodiversity and molecular biological research are comparatively limited with regard to the number of generic and specific elements, previous schemas for describing the physical and digital objects need to be replaced or expanded by new elements for covering the requirements from meta-omics techniques and operational details. On the one hand, schemas and standards are hitherto mostly focussed on elements, descriptors, or concepts that are relevant for data exchange and publication, on the other hand, detailed operational aspects regarding origin context and laboratory processing, as well as data management details, like the documentation of physical and digital object identifiers, are rather neglected.The conceptual schema for Meta-omics Data and Collection Objects (MOD-CO; https://www.mod-co.net/) has been set up recently Rambold et al. 2019. It includes design elements (descriptors or concepts), describing structural and operational details along the work- and dataflow from gathering environmental samples to the various transformation, transaction, and measurement steps in the laboratory up to sample and data publication and archiving. The concepts are named according to a multipartite naming structure, describing internal hierarchies and are arranged in concept (sub-)collections. By supporting various kinds of data record relationships, the schema allows for the concatenation of individual records of the operational segments along a workflow (Fig. 1). Thus, it may serve as a logical and structural backbone for laboratory information management systems. The concept structure in version 1.0 comprises 653 descriptors (concepts) and 1,810 predefined descriptor states, organised in 37 concept (sub-)collections. The published version 1.0 is available as various schema representations of identical content (https://www.mod-co.net/wiki/Schema_Representations). A normative XSD (= XML Schema Definition) for the schema version 1.0 is available under http://schema.mod-o.net/MOD-CO_1.0.xsd.The MOD-CO concepts might be integrated as descriptor/element structures in the relational database DiversityDescriptions (DWB-DD) an open-source and freely available software of the Diversity Workbench (DWB; https://diversityworkbench.net/Portal/DiversityDescriptions; https://diversityworkbench.net). Currently, DWB-DD is installed at the Data Center of the Bavarian Natural History Collections (SNSB) to build an instance of its own for storing and maintaining MOD-CO-structured meta-omics research data packages and enrich them with ‘metadata’ elements from the community standards Ecological Markup Language (EML), Minimum Information about any (x) Sequence (MIxS), Darwin Core (DwC) and Access to Biological Collection Data (ABCD). These activities are achieved in the context of ongoing FAIR ('Findable, Accessible, Interoperable and Reuseable') biodiversity research data publishing via the German Federation for Biological Data (GFBio) network (https://www.gfbio.org/). Version 1.1 of the schema with extended collections of structural and operational design concepts is scheduled for 2020.

【 授权许可】

Unknown