Regular smoking of male ancestors in adolescence and fat mass in young adult grandchildren and great-grandchildren

Wellcome Open Research

article

Steven Gregory¹  Matthew Suderman¹  Kate Northstone¹  Marcus Pembrey¹  Sarah Watkins¹  Yasmin Iles-Caven¹  Jean Golding¹ 

[1] Bristol Medical School ,(Population Health Sciences), University of Bristol

关键词: ALSPAC;    cigarette smoking;    adolescence;    grandparents;    fat mass;    lean mass;    intergenerational effects;    great-grandparents;   

DOI  :  10.12688/wellcomeopenres.17950.2

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Background: Previous studies using the Avon Longitudinal Study of Parents and Children (ALSPAC) have shown that if men commenced smoking prior to the onset of puberty their sons, their granddaughters and great-granddaughters were more likely to have excess fat (but not lean) mass during childhood, adolescence and early adulthood. In this study we assess associations between ancestral smoking during adolescence (ages 11–16 years) with fat and lean mass of subsequent generations at two ages.Methods: We analysed data on exposures of grandparents and great-grandparents collected by ALSPAC. The outcomes were the fat masses of their grandchildren and great-grandchildren measured at ages 17 and 24. Measures of lean mass were used as controls. Adjustment was made for 8–10 demographic factors using multiple regression.Results: We found associations between adolescent smoking of thepaternal grandfathers and the adjusted fat mass of their grandchildren, but no associations with the grandchildren’s lean mass. Grandchildren at age 17 had an average excess fat mass of +1.65 [95% CI +0.04, +3.26] Kg, and at age 24 an average excess of +1.55 [95% CI -0.27, +3.38] Kg. Adolescent smoking by thematernal grandfather showed similar, but weaker, associations: at 17 an average excess fat mass of +1.02 Kg [95% CI -0.20, +2.25] Kg, and at 24 an average excess of +1.28 [95% CI -0.11, +2.66] Kg. There were no pronounced differences between the sexes of the children. For the great-grandparents there were few convincing results, although numbers were small.Conclusions: We have shown associations between grandfathers’ smoking in adolescence and increased fat (but not lean) mass in their children. Confirmation of these associations is required, either in a further data set or by demonstrating the presence of supportive biomarkers.

【 授权许可】

CC BY