The genome sequence of the Australian filarial nematode, Cercopithifilaria johnstoni

Wellcome Open Research

article

Kirsty McCann¹  Warwick Grant¹  Stephen R. Doyle² 

[1] Department of Physiology, Anatomy & Microbiology, La Trobe University;Parasites & Microbes Programme, Wellcome Sanger Institute

关键词: Cercopithifilaria johnstoni;    filarial nematode;    genome assembly;    Illumina MiSeq;   

DOI  :  10.12688/wellcomeopenres.17258.2

学科分类：内科医学

来源: Wellcome

【 摘 要 】

We present a genome assembly and annotation of an individual femaleCercopithifilaria johnstoni, a parasitic filarial nematode that is transmitted by hard ticks (Ixodidae) to infect a broad range of native Australian murid and marsupial hosts. The genome sequence is 76.9 Mbp in length, and although in draft form (N50 = 99 kbp, N50[n] = 232), is largely complete based on universally conserved orthologs (BUSCOs; genome = 94.9%, protein = 96.5%) and relative to other related filarial species. These data represent the first genomic resources for the genusCercopithifilaria, a group of parasites with a broad host range, and form the basis for comparative analysis with the human-infective parasite,Onchocerca volvulus, both of which are responsible for similar eye and skin pathologies in their respective hosts.

【 授权许可】

CC BY