Research priorities for neuroimmunology: identifying the key research questions to be addressed by 2030

Wellcome Open Research

article

Georgina MacKenzie¹  Sumithra Subramaniam¹  Lindsey J Caldwell¹  Denise Fitzgerald³  Neil A Harrison⁴  Soyon Hong⁶  Sarosh R Irani⁷  Golam M Khandaker⁹  Adrian Liston^1,12  Veronique E Miron^1,13  Valeria Mondelli^1,14  B Paul Morgan^1,16  Carmine Pariante^1,15  Divya K Shah¹  Leonie S Taams^1,18  Jessica L Teeling^1,19  Rachel Upthegrove^2,20 

[1] Wellcome Trust;UK Dementia Research Institute Headquarters;Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast;Cardiff University Brain Research Imaging Centre ,(CUBRIC), Cardiff University;Division of Psychological Medicine and Clinical Neuroscience, Cardiff University;UK Dementia Research Institute, Institute of Neurology, University College London;Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford;Department of Neurology, Oxford University Hospitals NHS Foundation Trust;MRC integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol;Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol;Department of Psychiatry, University of Cambridge School of Clinical Medicine, University of Cambridge;Laboratory of Lymphocyte Signalling and Development, The Babraham Institute;UK Dementia Research Institute at The University of Edinburgh, Centre for Discovery Brain Sciences, University of Edinburgh;National Institute for Health Research, Mental Health Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and King's College London;Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London;UK Dementia Research Institute, Cardiff University;Systems Immunity Research Institute, Cardiff University;Centre for Inflammation Biology & Cancer Immunology, Department of Inflammation Biology, School of Immunology & Microbial Sciences, King's College London;Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton;Early Intervention Service, Birmingham Womens and Children’s NHS Foundation Trust;Institute for Mental Health, University of Birmingham

关键词: Peripheral nervous system;    central nervous system;    psychoneuroimmunology;    immunopsychiatry;    behaviour;    mental health;    inflammation;    neuroimmune interactions;   

DOI  :  10.12688/wellcomeopenres.16997.1

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Neuroimmunology in the broadest sense is the study of interactions between the nervous and the immune systems. These interactions play important roles in health from supporting neural development, homeostasis and plasticity to modifying behaviour. Neuroimmunology is increasingly recognised as a field with the potential to deliver a significant positive impact on human health and treatment for neurological and psychiatric disorders. Yet, translation to the clinic is hindered by fundamental knowledge gaps on the underlying mechanisms of action or the optimal timing of an intervention, and a lack of appropriate tools to visualise and modulate both systems. Here we propose ten key disease-agnostic research questions that, if addressed, could lead to significant progress within neuroimmunology in the short to medium term. We also discuss four cross-cutting themes to be considered when addressing each question: i) bi-directionality of neuroimmune interactions; ii) the biological context in which the questions are addressed (e.g. health vs disease vs across the lifespan); iii) tools and technologies required to fully answer the questions; and iv) translation into the clinic. We acknowledge that these ten questions cannot represent the full breadth of gaps in our understanding; rather they focus on areas which, if addressed, may have the most broad and immediate impacts. By defining these neuroimmunology priorities, we hope to unite existing and future research teams, who can make meaningful progress through a collaborative and cross-disciplinary effort.

【 授权许可】

CC BY