Non-Invasive measurement of the cerebral metabolic rate of oxygen using MRI in rodents

Wellcome Open Research

article

Tobias C Wood¹  Diana Cash¹  Eilidh MacNicol¹  Camilla Simmons¹  Eugene Kim¹  David J Lythgoe¹  Fernando Zelaya¹  Federico Turkheimer¹ 

[1] Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London

关键词: MRI;    CMRO2;    CBF;    OEF;    Glucose;    Metabolism;   

DOI  :  10.12688/wellcomeopenres.16734.4

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Malfunctions of oxygen metabolism are suspected to play a key role in a number of neurological and psychiatric disorders, but this hypothesis cannot be properly investigated without anin-vivo non-invasive measurement of brain oxygen consumption. We present a new way to measure the Cerebral Metabolic Rate of Oxygen (CMRO2) by combining two existing magnetic resonance imaging techniques, namely arterial spin-labelling and oxygen extraction fraction mapping. This method was validated by imaging rats under different anaesthetic regimes and was strongly correlated to glucose consumption measured by autoradiography.

【 授权许可】

CC BY