MendelianRandomization v0.5.0: updates to an R package for performing Mendelian randomization analyses using summarized data

Wellcome Open Research

article

Jim R. Broadbent¹  Christopher N. Foley²  Andrew J. Grant²  Amy M. Mason¹  James R. Staley¹  Stephen Burgess¹ 

[1] Cardiovascular Epidemiology Unit, University of Cambridge;MRC Biostatistics Unit, University of Cambridge

关键词: Mendelian randomization;    instrumental variable;    summarized data;    genetic epidemiology;    post-GWAS analysis;    causal inference;    genetic associations.;   

DOI  :  10.12688/wellcomeopenres.16374.2

学科分类：内科医学

来源: Wellcome

【 摘 要 】

The MendelianRandomization package is a software package written for the R software environment that implements methods for Mendelian randomization based on summarized data. In this manuscript, we describe functions that have been added to the package or updated in recent years. These features can be divided into four categories: robust methods for Mendelian randomization, methods for multivariable Mendelian randomization, functions for data visualization, and the ability to load data into the package seamlessly from the PhenoScanner web-resource. We provide examples of the graphical output produced by the data visualization commands, as well as syntax for obtaining suitable data and performing a Mendelian randomization analysis in a single line of code.

【 授权许可】

CC BY