Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments

Wellcome Open Research

article

Mark J. Adams¹  Archie I. Campbell¹  Donald J. MacIntyre¹  Alison Pattie¹  Lee Murphy¹  Rebecca M. Reynolds²  Rebecca Elliot³  Ian S. Penton-Voak⁴  Marcus R. Munafò⁴  Kathryn L. Evans¹  Jonathan R. Seckl¹  Joanna M. Wardlaw¹  Stephen M. Lawrie¹  Christopher S. Haley¹  David J. Porteous¹  Ian J. Deary¹  Alison D. Murray⁵  Tina Habota⁵  Anca-Larisa Sandu⁵  Gordon D. Waiter⁵  Christopher J. McNeil⁵  J. Douglas Steele⁶  Jennifer A. Macfarlane⁷  Heather C. Whalley¹  Ruth Valentine⁵  Dawn Younie⁵  Nichola Crouch⁵  Emma L. Hawkins¹  Yoriko Hirose¹  Liana Romaniuk¹  Keith Milburn⁶  Gordon Buchan⁵  Tessa Coupar⁶  Mairi Stirling⁶  Baljit Jagpal⁶  Beverly MacLennan⁵  Lucasz Priba⁶  Mathew A. Harris¹  Jonathan D. Hafferty¹  Andrew M. McIntosh¹ 

[1] University of Edinburgh;Queen’s Medical Research Institute;University of Manchester;University of Bristol;University of Aberdeen;University of Dundee;Ninewells Hospital & Medical School

关键词: Cognition;    Depression;    Generation Scotland;    Longitudinal;    Neuroimaging;    Psychological resilience;   

DOI  :  10.12688/wellcomeopenres.15538.2

学科分类：内科医学

来源: Wellcome

【 摘 要 】

STratifying Resilience and Depression Longitudinally (STRADL) is a population-based study built on the Generation Scotland: Scottish Family Health Study (GS:SFHS) resource. The aim of STRADL is to subtype major depressive disorder (MDD) on the basis of its aetiology, using detailed clinical, cognitive, and brain imaging assessments. The GS:SFHS provides an important opportunity to study complex gene-environment interactions, incorporating linkage to existing datasets and inclusion of early-life variables for two longitudinal birth cohorts. Specifically, data collection in STRADL included: socio-economic and lifestyle variables; physical measures; questionnaire data that assesses resilience, early-life adversity, personality, psychological health, and lifetime history of mood disorder; laboratory samples; cognitive tests; and brain magnetic resonance imaging. Some of the questionnaire and cognitive data were first assessed at the GS:SFHS baseline assessment between 2006-2011, thus providing longitudinal measures relevant to the study of depression, psychological resilience, and cognition. In addition, routinely collected historic NHS data and early-life variables are linked to STRADL data, further providing opportunities for longitudinal analysis. Recruitment has been completed and we consented and tested 1,188 participants.

【 授权许可】

CC BY