Is diabetes associated with malaria and malaria severity? A systematic review of observational studies

Wellcome Open Research

article

Rodrigo M. Carrillo-Larco¹  Carlos Altez-Fernandez⁴  Cesar Ugarte-Gil⁴ 

[1] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London;CRONICAS Centre of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia;Centro de Estudios de Poblacion, Universidad Catolica los Ángeles de Chimbote;Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia;Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia;Department of Clinical Research, London School of Hygiene and Tropical Medicine;Department of International Health, Johns Hopkins Bloomberg School of Public Health

关键词: malaria;    diabetes;    multi-morbidity;    co-morbidity;    syndemics;    Peru;   

DOI  :  10.12688/wellcomeopenres.15467.3

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Background: We conducted a systematic review to study the association between diabetes and malaria as well as malaria severity.Methods: The search was conducted in Embase, Global Health, MEDLINE, Scopus and Web of Science. Titles and abstracts were screened, full-text studied and information extracted for qualitative synthesis. Risk of bias was assessed with ROBINS-I criteria. The exposure was diabetes and the outcome malaria or malaria severity.Results: Of 1992 results, three studies were included (n=7,226). Two studies found strong associations: people with diabetes had higher odds of malaria (adjusted odds ratio (aOR): 1.46 (95% CI: 1.06-2.03)) and severe malaria (aOR: 2.98 (95% CI: 1.25-7.09)). One study did not find conclusive evidence: aOR for severe malaria was 0.95 (95% CI: 0.71-1.28). Risk of bias was high in all the studies.Conclusions: Although the available evidence on the association between diabetes and malaria is limited, the results may suggest there is a non-trivial positive relationship between these conditions.

【 授权许可】

CC BY