Small for gestational age babies and depressive symptoms of mothers during pregnancy: Results from a birth cohort in India

Wellcome Open Research

article

Giridhara R. Babu¹  G.V.S. Murthy³  Yogesh Reddy¹  R. Deepa¹  A. Yamuna¹  S. Prafulla¹  Anjaly Krishnan¹  Eunice Lobo¹  Mohanbabu Rathnaiah⁵  Sanjay Kinra⁶ 

[1] Indian Institute of Public Health - Bangalore;The Wellcome Trust/DBT India Alliance;Indian Institute of Public Health, Public Health Foundation of India;International Centre for Eye Health, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine;Department of Psychiatry, Institute of Mental Health, University of Nottingham;Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine

关键词: Small for Gestational age;    low birth weight;    Prenatal depression;    Screening;    Pregnancy;    birth cohort;    public hospital;    Low and Middle Income Country;   

DOI  :  10.12688/wellcomeopenres.14618.3

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Background: Annually, more than a million low birthweight (LBW) is born in India, often afflicting disadvantaged families. Several studies have undertaken the association of poverty, nutritional status, and obstetric factors with LBW. Through our study, we aimed to examine the possibility of any relation between the Edinburgh Postnatal Depression Scale (EPDS) score measured during pregnancy with the incidence of babies born Small for Gestational Age (SGA).Methods: Pregnant women attending the antenatal clinic at a public hospital between 14 to 32 weeks were recruited from April 2016 to Oct 2017. The EPDS was administered to assess depression through face-to-face interviews. Newborn anthropometry was performed post-delivery. For analysis, birth weight <10 percentile was classified as SGA.Results11 (adjusted OR = 2.03; 95% CI = 1.12 – 3.70) compared to the women with EPDS scores of ≤11, The EPDS 12 (Adjusted OR = 1.96; 95% CI = 1.04 – 3.69) and EPDS 13 (Adjusted OR = 2.42; 95% CI = 1.24 – 4.70) cut-off categories also proved to be a risk factor for SGA with significant p-value (0.0006 and 0.0003) and the individuals with more than 13 EPDS score is found to have the highest odds of SGA.Conclusions: We found a strong association of antenatal depressive symptoms during pregnancy with SGA measured by EPDS. Thus, we recommend the implementation of timely and effective screening, diagnostic services, and evidence-based antenatal mental health services to combat SGA and further associated-metabolic syndromes.

【 授权许可】

CC BY