DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic pain

Wellcome Open Research

article

Mathilde M.V. Pascal¹  Andreas C. Themistocleous¹  Ralf Baron²  Andreas Binder²  Didier Bouhassira³  Geert Crombez⁴  Nanna B. Finnerup⁵  Janne Gierthmühlen²  Yelena Granovsky⁷  Leif Groop⁸  Harry L. Hebert⁹  Troels S. Jensen⁶  Kristinn Johnsen^1,10  Mark I. McCarthy^1,11  Weihua Meng⁹  Colin N.A. Palmer^1,12  Andrew S.C. Rice^1,13  Jordi Serra^1,14  Romà Solà^1,14  David Yarnitsky⁷  Blair H. Smith⁹  Nadine Attal³  David L.H. Bennett¹ 

[1] Nuffield Department of Clinical Neurosciences, University of Oxford;Division of Neurological Pain Research and Therapy, Department of Neurology, Universitätsklinikum Schleswig-Holstein;INSERM U-987, Centre d'Evaluation et de Traitement de la Douleur, APHP, CHU Ambroise Paré, Boulogne-Billancourt, France and University Versailles Saint Quentin en Yvelines;Department of Experimental-Clinical and Health Psychology, Ghent University;Department of Clinical Medicine, Danish Pain Research Center, Aarhus University;Department of Neurology, Aarhus University Hospital;Department of Neurology, Rambam Health Care Campus, Technion Faculty of Medicine;Department of Clinical Sciences, Diabetes and Endocrinology, University of Lund;Division of Population Health Sciences, University of Dundee;MentisCura;Wellcome Trust Centre for Human Genetics, University of Oxford;Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and School of Medicine, University of Dundee;Pain Research Group, Imperial College London;Neuroscience Technologies, Ltd

关键词: pain;    neuropathy;    neuropathic pain;    diabetes;    nerve injury;    risk factors;    protocol;   

DOI  :  10.12688/wellcomeopenres.14576.2

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Background: Neuropathic pain is an increasingly prevalent condition and has a major impact on health and quality of life. However, the risk factors for the development and maintenance of neuropathic pain are poorly understood. Clinical, genetic and psychosocial factors all contribute to chronic pain, but their interactions have not been studied in large cohorts. The DOLORisk study aims to study these factors.Protocol: Multicentre cross-sectional and longitudinal cohorts covering the main causes leading to neuropathic pain (e.g. diabetes, surgery, chemotherapy, traumatic injury), as well as rare conditions, follow a common protocol for phenotyping of the participants. This core protocol correlates answers given by the participants on a set of questionnaires with the results of their genetic analyses. A smaller number of participants undergo deeper phenotyping procedures, including neurological examination, nerve conduction studies, threshold tracking, quantitative sensory testing, conditioned pain modulation and electroencephalography.Ethics and dissemination: All studies have been approved by their regional ethics committees as required by national law. Results are disseminated through theDOLORisk website, scientific meetings, open-access publications, and in partnership with patient organisations.

【 授权许可】

CC BY