Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort

Wellcome Open Research

article

Ruth E. Mitchell¹  Hannah J. Jones¹  Robert H. Yolken⁴  Glen Ford⁴  Lorraine Jones-Brando⁴  Susan M. Ring¹  Alix Groom¹  Sophie FitzGibbon⁵  George Davey Smith¹  Nicholas J. Timpson¹ 

[1] Medical Research Council Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol;Centre for Academic Mental Health, Population Health Sciences, Bristol Medical School, University of Bristol;National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and University of Bristol;Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine;Population Health Sciences, Bristol Medical School, University of Bristol

关键词: Infection;    antibody;    ALSPAC;   

DOI  :  10.12688/wellcomeopenres.14565.2

学科分类：内科医学

来源: Wellcome

【 摘 要 】

Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Plasma was collected during clinics at age 5, 7, 11 and 15 years. The antigens examined include: fungal (Saccharomyces cerevisiae); protozoan (Toxoplasma gondii and surface antigen 1 of T. gondii); herpes viruses (cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1); common colds (influenza virus subtypes H1N1 and H3N2); other antigens (measles); animal (feline herpes virus, Theiler’s virus); bacteria (Helicobacter pylori); dietary antigens (bovine casein alpha protein, bovine casein beta protein). Alongside the depth of data available within the ALSPAC cohort, this longitudinal resource will enable the investigation of the association between infections and a wide variety of outcomes.

【 授权许可】

CC BY