Gene Regulation by p53 in Human Cancer System

Asian Pacific Journal of Cancer Biology

article

Supratit Ghosh¹  Meghna Bhattacharjee¹  Nandan Kumar Jana³ 

[1] Department of Life science and Biotechnology;Jadavpur University;Department of Biotechnology, Heritage Institute of Technology

关键词: p53 Transcription autoregulation;    mutation hotspots;    Gain of Function;    Dominant negative effect;    Chemoresistance;   

DOI  :  10.31557/apjcb.2022.7.1.97-109

学科分类：土木及结构工程学

来源: West Asia Organization for Cancer Prevention

【 摘 要 】

T transitions in TP53, giving rise to mutation hotspots in R248, R273, etc. In addition to the loss of function, mutations in the TP53 gene also confers oncogenic functions that are not found in wild type p53, referred to as Gain of Function (GOF). GOF mutp53 has been found to promote metastasis, cell proliferation, cell stemness, metabolic reprogramming as well as chemoresistance. Mutp53 also inhibits the wild type effect that is referred to as the Dominant negative effect (DNE). Understanding the mechanisms behind GOF activities, how they promote chemoresistance, and targeting mutp53 will help in improving the treatment of many human cancers with TP53 mutations.

【 授权许可】

CC BY