Prognostic Impact on Survival of Early Relapse after Autologous Stem Cell Transplantation with Non-cryopreserved Stem Cells for Multiple Myeloma in Real Life: A Single-center Cohort Study from Oran (Algeria)

Asian Pacific Journal of Cancer Biology

article

Mohamed Amine Bekadja¹  Belkacem Mansour²  Hafida Ouldjeriouat²  Laurent Garderet³  Brahim Benzineb⁴  Samira Bouchama²  Leila Charef²  Badra Entasoltan²  Nabil Yafour²  Sofiane Belaidi⁵ 

[1] HEMATOLOGY AND CELL THERAPY DEPARTMENT EHU Oran;Department of Hematology and Cell Therapy, 1er Novembre University Hospital, Ahmed Benbella 1 University;Department of Hematology, Pitié-Salpêtrière Hospital;Department of Hematology, University Hospital of Tlemcen;1 Department of Hematology and Cell Therapy, 1er Novembre University Hospital, Ahmed Benbella 1 University

关键词: Key words: multiple myeloma;    autologous transplant;    early relapse;   

DOI  :  10.31557/apjcb.2022.7.1.15-20

学科分类：土木及结构工程学

来源: West Asia Organization for Cancer Prevention

【 摘 要 】

Background: The aim of this retrospective study was to analyze early relapse in multiple myeloma (MM) in real life and to evaluate its impact on overall survival (OS) and progression-free survival (PFS). Methods: Two groups of patients were identified according to the date of occurrence of relapse after autologous transplantation, within less than 24 months, defining early relapse (G1), or after more than 24 months, defining late relapse (G2). Results:12 months (p=0.02) and an absence of maintenance therapy (p=0.002) were predictive of early relapse. Conclusion: The predictive factors identified here should allow us to adapt the therapeutic strategy.

【 授权许可】

CC BY