Comparison of Clinical Characteristic and Survival Outcomes between Clear Cell and Non-Clear Cell Ovarian Cancer

Thai Journal of Obstetrics and Gynaecology

article

PhornsawanWasinghon¹  Kobkarn Champoonot¹  AuttayaRatakaew¹  PallopPongsuthirak¹ 

[1]Department of Obstetrics and Gynecology, Buddhachinaraj Hospital

关键词: clear cell adenocarcinoma;    epithelial ovarian cancer;    survival analysis;   

DOI  :  10.14456/tjog.2023.3

学科分类：社会科学、人文和艺术（综合）

来源: The Royal Thai College of Obstetricians and Gynaecologists

【 摘 要 】

Objectives: To compare clinical characteristics and survival outcomes between women with clear cell carcinoma (CCC) and non-clear cell (NCC) epithelium ovarian cancer. Materials and Methods: A retrospective cohort study was conducted on 220 Epithelial ovarian cancer (EOC) patients at Buddhachinaraj Hospital between January 1999 and May 2017. The patient data were retrieved from medical records. The patient characteristic, operative findings, histologic types, chemotherapy, time of recurrence, and follow-up time were analyzed. The medical records were comprehensively reviewed. The Kaplan-Meier method and Cox regression were employed in the survival analyses.Results: A total of 220 EOC patients were eligible in the study, comprising 63 cases of CCC and 150 cases of NCC. Patients with CCC were more presented stage I and met optimal cytoreduction (p < 0.005). The progression-free survival (PFS) and overall survival (OS) were not statistically different between CCC and NCC when analyzed in all stages. However, PFS and OS were significantly different when classified EOC into three groups: NCC type I, type II EOC, and CCC. In stage I, CCC had better PFS (p = 0.007), but OS was no significant difference (p = 0.279). In stage II-IV, CCC had a trend toward poorer 5-year OS than type II EOC. The optimal surgery and complete course of platinum-based chemotherapy were associated with better survival outcomes in patients with epithelial ovarian cancer (p < 0.001). Conclusion: The prevalence of CCC was 29.65% of EOC patients, and the majority found stage I. The PFS and OS were not statistically different between CCC and NCC.

【 授权许可】

CC BY-NC-ND