Prevention of venous thromboembolism with aspirin following knee surgery: A systematic review and meta-analysis

EFORT Open Reviews

article

Stephanie Marrannes¹  Klaas Victor²  Nele Arnout¹  Tine De Backer³  Jan Victor¹  Thomas Tampere¹ 

[1] Department of Orthopedic Surgery, Ghent University;Department of Orthopedic Surgery, University of Leuven;Department of Cardiology, Ghent University

关键词: aspirin;    thromboprophylaxis;    VTE;   

DOI  :  10.1302/2058-5241.6.200120

学科分类：神经科学

来源: The British Editorial Society of Bone & Joint Surgery

【 摘 要 】

Venous thromboembolism (VTE) is a well-known complication following orthopaedic surgery. The incidence of this complication has decreased substantially since the introduction of routine thromboprophylaxis. However, concerns have been raised about increased bleeding complications caused by aggressive thromboprophylaxis. Attention has grown for aspirin as a safer thromboprophylactic agent following orthopaedic surgery. A systematic review using MEDLINE, Embase and Web of Science databases was undertaken to compare the effectiveness of aspirin prophylaxis following knee surgery with the current standard prophylactic agents (low molecular weight heparin [LMWH], vitamin K antagonists and factor Xa inhibitors). No significant difference in effectiveness of VTE prevention was found between aspirin, LMWH and warfarin. Factor Xa inhibitors were more effective, but increased bleeding complications were reported. As evidence is limited and of low quality with substantial heterogeneity, further research with high-quality, adequately powered trials is needed.

【 授权许可】

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