Prognostic Role of Measurement of Renal Resistive Index in Systemic Sclerosis

Mediterranean Journal of Rheumatology

article

Shefali Khanna Sharma¹  Arghya Chattopadhyay¹  Siddharth Jain¹  Chitra Raj Sharma²  Debashish Mishra¹  Manish Rathi³  Mahesh Prakash⁴  Sanjay Jain¹ 

[1] Clinical Immunology and Rheumatology Division Postgraduate Institute of Medical Education and Research;Department of Internal Medicine, Postgraduate Institute of Medical Education and Research;Department of Nephrology, Postgraduate Institute of Medical Education and Research;Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research

关键词: vasculopathy;    systemic sclerosis;    renal resistive index;    renal doppler indices;    pulmonary hypertension;    digital ulcers;    proteinuria;   

DOI  :  10.31138/mjr.32.4.345

学科分类：社会科学、人文和艺术（综合）

来源: PCO Convin S.A.

【 摘 要 】

Objective: The spectrum of vascular involvement in systemic sclerosis (SSc) includes digital ulcers, gangrene, Raynaud's phenomenon, renovascular disease, and pulmonary hypertension (PH). Recognition of markers of subclinical vascular disease in SSc is an area of active research, but such studies are limited. This study assesses the role of measurement of the renal resistive index (RRI) as an early marker of renal and systemic vasculopathy. It is a step forward towards examining the possibility of a “unified vascular phenotype’ in SSc. Methods:0.7) was correlated with renal function (eGFR and proteinuria) and systemic vasculopathy manifestations like digital ulcers, digital infarcts, and PH. Results:0.7). A strong negative correlation was noted between elevated RRI and eGFR (r= -0.96, p=0.03). The percentage of patients with overt proteinuria was higher in the group with elevated RRI (20% versus 7%) (p=0.16). Similarly, digital ulcers (56% vs 33%) and digital pitting (50% vs 35%.) were numerically higher in the group with raised RRI, although statistical significance was not reached because of small numbers (p=0.09 and 0.28, respectively). No correlation of RRI with PH was identified. Conclusion: RRI correlates well with asymptomatic renal dysfunction and holds promise in the assessment of systemic vasculopathy. However, validation in studies with a larger sample size is needed.

【 授权许可】

CC BY-NC