Ergotamine Induced Retroperitoneal Fibrosis

Mediterranean Journal of Rheumatology

article

Susama Patra¹  Somanath Padhi¹  Prasanta Padhan²  Madhabananda Kar³  Prasant Nayak⁴  Subash Chandra Samal⁵ 

[1] Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences;Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences, KIIT University;Department of Surgical Oncology, All India Institute of Medical Sciences;Department of Urology, All India Institute of Medical Sciences;Department of Gastroenterology, All India Institute of Medical Sciences

关键词: RPF;    vasculitis;    ergotamine;   

DOI  :  10.31138/mjr.32.2.168

学科分类：社会科学、人文和艺术（综合）

来源: PCO Convin S.A.

【 摘 要 】

Retroperitoneal fibrosis (RPF) is an uncommon disease characterised by the presence of fibroinflammatory reaction which starts around the infrarenal portion of the abdominal aorta in the retroperitoneum and frequently entrap the ureter causing obstructive uropathy. Approximately, two thirds of the cases are idiopathic, where aetiopathogenesis is not known. Ergotamine-induced RPF, although rare, is considered under secondary group. The fibrogenic process here is thought to be due to serotonergic activity. We report a case of RPF in a young female with obstructive uropathy who had history of long-term ergotamine intake for migraine. Histopathological evaluation revealed different evolving stages of necrotising vasculitis. In addition, the patient has responded to withdrawal of offending drug along with immunosuppressive therapy. We believe, apart from serotonergic activity, ergotamine can lead to RPF through a vasculitic process which has not been reported earlier.

【 授权许可】

CC BY-NC